A stepping stone to develop bioinformatics in Pakistan

A Stepping Stone to Pluripotency

Somatic cells can be reprogrammed into pluripotent stem cells via either expression of transcription factors or addition of small molecule chemicals only. Zhao et al. reveal a unique intermediate state during chemical reprogramming allowing a significant improvement in its efficiency and kinetics.

Imitation as a Stepping Stone to Innovation

By creating a knowledge base that reduces innovation costs, imitation can serve as a stepping stone enabling …rms from lagging countries to undertake innovation. This paper constructs a product cycle model with this feature to determine what forces could cause a lagging country to shift R&D from imitation toward innovation. Increasing resources or subsidizing R&D in the lagging South increases ...

Stepping Stone Detection Analysis

A stepping stone in treating dendritic keratitis

Purpose To report the outcome of self-retained amniotic membrane after debridement in recurrent dendritic keratitis. Observations A 70-year-old female with a recurrent dendritic corneal ulcer received debridement followed by placement of self-retained amniotic membrane. Five days after treatment, the patient experienced a complete resolution of symptoms, marked reduction of inflammation, comp...

A stumbling block or a stepping stone?

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and...